Runx2, Osx, and Dspp in Tooth Development
نویسندگان
چکیده
منابع مشابه
Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development
Supernumerary teeth and tooth agenesis are common morphological anomalies in humans. We previously obtained evidence that supernumerary maxillary incisors form as a result of the successive development of the rudimentary maxillary incisor tooth germ in Usag-1 null mice. The development of tooth germs is arrested in Runx2 null mice, and such mice also exhibit lingual epithelial buds associated w...
متن کاملDifferent Methylation Patterns of RUNX2, OSX, DLX5 and BSP in Osteoblastic Differentiation of Mesenchymal Stem Cells
OBJECTIVE Runt-related transcription factor 2 (RUNX2) and osterix (OSX) as two specific osteoblast transcription factors and distal-less homeobox 5 (DLX5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (BSP), osteopontin and collagen type Iα1. The present study sets out to investigate whether epigenetic regulatio...
متن کاملDifferential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation.
Dentin sialophosphoprotein (DSPP) consists of dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). The spatial-temporal expression of DSPP is largely restricted during differentiational stages of dental cells. DSPP plays a vital role in tooth development. It is known that an osteoblast-specific transcription factor, Runx2, is essential for osteoblast differentiation. However, effects of R...
متن کاملBHE 014 The Interrelationship of Runx2 and Osx and Differentiation, Potential Therapeutic Implications
Non-viral based gene therapies represent one possible tissue engineering-based approach to improve bone regeneration. Unique target proteins for gene therapy are transcription factors. These are nuclear based proteins that can not feasibly be applied as mature proteins. Therefore, protein based therapies can not be utilized. Gene therapy is the only option. However, it remains unclear which tra...
متن کاملdifferent methylation patterns of runx2, osx, dlx5 and bsp in osteoblastic differentiation of mesenchymal stem cells
objective: runt-related transcription factor 2 (runx2) and osterix (osx) as two specific osteoblast transcription factors and distal-less homeobox 5 (dlx5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (bsp), osteopontin and collagen type iα1. the present study sets out to investigate whether epigenetic regulati...
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ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2009
ISSN: 0022-0345,1544-0591
DOI: 10.1177/0022034509342873